5th International Symposium on the Environmental Dimension of Antibiotic Resistance

9–14 June 2019 • Hong Kong

5th International Symposium on the Environmental Dimension of Antibiotic Resistance

9–14 June 2019 • Hong Kong

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Pascal Simonet (France)
CNRS Research Director
University of Lyon 

Pascal Simonet’s research group has had the general objectives of determining the involvement of horizontal gene transfers (HGT) in the adaptation and evolution of bacteria to new environments and was among the first to investigate environmental bacteria with metagenomic approaches. Several of his group’s studies were devoted to investigate the fate of DNA released by genetically engineered organisms including the possibility that antibiotic resistance genes transform indigenous bacteria. This led them to investigate the natural occurrence and the fate of antibiotic resistance genes in the environment and their potential to be transferred to pathogens. Using metagenomic sequences, they show that ARGDs can be detected in all environments analyzed being an abundant reservoir of potentially transferable resistance for pathogens. Soil metagenomes had the most diverse pool of ARGDs and his study described the diverse and abundant antibiotic resistance genes in nonclinical environments and shows that these genes are not randomly distributed among different environments.